Medical progress

Is this a cure for Alzheimer’s? Jab that improved memory and brain function in mice within a WEEK is to be tested on humans

Scientists make ‘encouraging’ discovery that the so-called IL-33 protein can reverse cognitive decline

THERE are fresh hopes for Alzheimer’s sufferers after scientists discovered that a protein lacking in their brain could provide the key to potential treatment.

 

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Researchers say the discovery that the IL-33 protein can reverse cognitive decline in mice is "encouraging".

 

Scientists looking into the treatment of Alzheimer's disease say they have made an 'encouraging' discovery

Mice with Alzheimer's-type disease were injected with IL-33 – and their memory and brain function rapidly improved within a week.

 

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It has already been established that the brain of Alzheimer's sufferers contains less of this particular protein than the brain of non-sufferers.

 

The latest study was led by scientists at Glasgow University and the Hong Kong University of Science and Technology (HKUST).

 

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Professor Eddy Liew, who co-directed the research, said the effects of this finding on human Alzheimer’s are not yet clear.

 

But he added: “There are encouraging hints.

 

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"For example, previous genetic studies have shown an association between IL-33 mutations and Alzheimer's disease in European and Chinese populations.

 

";Exciting as it is, there is some distance between laboratory findings and clinical applications.

 

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"There have been enough false 'breakthroughs' in the medical field to caution us not to hold our breath until rigorous clinical trials have been done. Nevertheless, this is a good start."

The new findings offer fresh hope for Alzheimer's sufferers

 

Alzheimer's symptoms include the presence of a type of deposit and neurofibrillary “tangles” in the brain.

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These build up and lead to the loss of connections between nerve cells and eventually to loss of brain tissue.

 

IL-33 appears to work by mobilising immune cells in the brain, reducing the number and size of the deposits.

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It also inhibits inflammation in the brain tissue, which is associated with deposits and tangles forming in the first place.

 

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