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THE number of Brits who have lost their lives to coronavirus is nearing 46,000 - as another 280 people die.

Meanwhile, 23,065 more have tested positive for the deadly bug.

⚠️ Read our coronavirus live blog for the latest news & updates

Another 280 people have lost their lives to Covid in the UK
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Another 280 people have lost their lives to Covid in the UK
Birmingham and the West Midlands look set to go into tier three restrictions in the coming days
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Birmingham and the West Midlands look set to go into tier three restrictions in the coming daysCredit: Caters News Agency
But Boris Johnson is resisting pressure to send the whole country into another lockdown
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But Boris Johnson is resisting pressure to send the whole country into another lockdownCredit: Caters News Agency
Wales is on the sixth full day of a firebreak lockdown designed to stem the surge of new cases
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Wales is on the sixth full day of a firebreak lockdown designed to stem the surge of new casesCredit: PA:Press Association

In total, 45,955 people have died with Covid since the UK's outbreak began.

However, there are encouraging signs the number of new infections is slowing.

Yesterday was the first time the daily number of cases has fallen on the amount recorded the week before since September 28.

The tally has dropped slightly again today.

It comes as:

Fatalities are beginning to increase after infections spiked when schools and universities reopened in September.

It often takes weeks for patients to become severely ill with the virus.

Yesterday, 310 new deaths were recorded, while on Tuesday, a further 367 people were reported to have died - the highest number in more than five months.

A further 192 people died in hospitals in England. Patients were aged between 27 and 101.

All but one - who was 63 - had known underlying health conditions.

The majority of fatalities - 73 - were in the north-west, while 31 people died in the north-east and Yorkshire, 43 in the Midlands and 24 in London.

Six people died in the east, while the south-east had seven deaths and the south-west eight.

In Scotland, 1,128 new cases of Covid were reported, and 37 people died.

Meanwhile, in Wales, there were 1,375 new positive tests and 21 deaths.

The UK recorded its biggest ever infection rise of 26,688 on Wednesday, October 21.

Officials say they believe the second wave will be deadlier than the first - as it'll last longer, despite never reaching April's peak
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Officials say they believe the second wave will be deadlier than the first - as it'll last longer, despite never reaching April's peak
The R rate could be higher than two in areas of the south, it's believed
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The R rate could be higher than two in areas of the south, it's believed

Despite rising cases, the Government looks set to continue resisting calls for a new national lockdown.

Housing Secretary Robert Jenrick today said Boris Johnson will refuse to bow to pressure from Sage scientists and politicians for a 'circuit-breaker' shutdown.

But the minister admitted the virus "is in a bad place in all parts of the country" as "frustrated" Brits face grinding local measures.

Business leaders and MPs have warned a second shutdown could devastate the UK's beleaguered economy.

Julian Metcalfe, the founder of Pret and Itsu, said another lockdown would be "impossible", adding: "Society will not recover if we do it again to save a few thousand lives of very old or vulnerable people. 

"The young people of this country will be paying for this for the next 20 to 30 years. It's terrible what's happening.

"Just because France does this with its socialist government, doesn't mean we have to."

Meanwhile, areas including Leeds and West Yorkshire are preparing for tougher restrictions. 

And Birmingham and the West Midlands are also reportedly heading into tier three measures.

Birmingham city council leader Ian Ward said officials "have to do something more" to stem increasing infections - and the region will fall under the toughest tier unless new cases slow.

Danger zones

Regions around the UK look set to face tougher measures as cases surge. They include:

Stockton-on-Tees, with 444.4 cases per 100,000 people, and 877 new infections

Leeds 420.6 (3336)

Wakefield 430.4 (1499)

Middlesbrough 393.0 (554)

Bristol 340.8 (1579)

Charnwood 437.4 (813)

Calderdale 441.2 (933)

South Staffordshire 364.7 (410)

North East Derbyshire 350.9 (356)

North East Lincolnshire 349.7 (558)

The city has a rate of 259 new cases per 100,000 residents. By comparison, Blackburn with Darwen - which remains the UK's worst-hit area - has a rate of 774.9 cases per 100,000 people.

More areas look set to face tougher lockdown restrictions in the coming weeks.

Stockton-on-Tees, with an infection rate of 444.4 per 100,000 people - up from 360 the week before - is at the top of the list of places at risk of tumbling into tier three.

Leeds has 420.6 cases per 100,000, while the infection rate in Bristol soared by roughly 50 per cent in the last week.

The city is still only in tier one - the lower Covid alert level. But it has moved itself into a 'tier one-plus' system - despite the Government saying the level doesn't exist.

Bath, Cambridge and Brighton are also all at risk of hurtling towards a tier two lockdown.

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The worrying figures come after Government scientists warned the death toll could be even greater in the second wave.

And Sage scientists have warned that by Christmas, virus rates all over the country will soar past the levels seen in areas already put into the “very high” category.

Home Secretary Priti Patel refuses to rule out lockdown to combat rise in coronavirus cases
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