the "prevailing understanding" that while vaccine breakthrough cases may occur, the infections would be mild.
She said: "But in contrast to that, what we saw among our 20 samples was that a number of them actually had quite robust viral loads.
"That was concerning in the sense that there was definitely enough virus to sequence, and potentially there might be enough virus to transmit."
None of the 20 patients studied were hospitalised and its unknown if they did pass on the disease to others.
Dr Roychoudhury said the high viral lands highlighted the importance of continuing self isolation - and added studies like this are key for help manufacturers develop booster shots to the beat the variants.
She emphasised that the study does not show the current vaccines are ineffective.
The doctor said: "A lot of the antibody responses are pretty broad.
"The vaccines are not designed to be super specific so they will be able to target the variants."
And she said as more and more people are vaccinated, the number of breakthrough cases are likely to come down as overall infection levels reduce.
Scientists and doctors are facing a race against time to vaccinate enough people to slow down the spread of the virus.
The virus's uncontrolled circulation allows it mutate, with regular warnings that this could spawn new variants which could overcome the jabs.
It has already been warned face masks and home working could stay beyond June 21 if the Indian variant continues to spread in the UK.
Britain's delay case count - which was down to lows of 1,614 at the start of May - has crept up to highs of 4,182.
Friday's number was the highest daily figure since April.
And yesterday, Vietnam announced it had discovered a Indian-UK variant hybrid which appeared to spread faster and more quickly replicate .
Professor Neil Ferguson, dubbed Prof Lockdown, previously said mutant strains could prevent the Government’s roadmap from going ahead as planned if it is more transmissible than previous variants.
He added that it could be another “two to three weeks” before it is clear whether the final step in lifting the lockdown can safely go ahead on June 21.
Meanwhile, Professor Ravi Gupta, professor of clinical microbiology at the University of Cambridge, has warned we could now see “super mutant viruses” emerge.
He said that while this would not necessarily be a bad thing, the virus would try to become more efficient at transmission as more people are protected.
Prof Gupta said that as vaccine coverage increases, for most people who get Covid-19 it will be a mild illness, even with the “super variants”, but there will always be some vulnerable people.
Chris Hopson, chief executive of NHS Providers, said the next week will be "crucial" as trusts analyse Indian variant data closely.
He said hospitals in Indian variant hotspots were seeing cases rise steadily and not at "an alarming rate".
Mr Hopson said: "The next seven days will be crucial, and trusts will be monitoring the data closely."
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