COPS are investigating whether a car was travelling the wrong way down the M6 killing two children, a woman and a man.
A Skoda and a Toyota were involved in the horror collision on the M6 northbound, near Tebay Services, at around 4.04pm yesterday.
Cumbria Police is understood to be probing whether the Skoda was travelling the wrong way along the motorway.
It comes after the force confirmed the driver of the Skoda, a man from Cambridgeshire, was pronounced dead at the scene.
A man, a woman and two children from Glasgow, who were in the Toyota, also died at the scene.
A third child, who was in the Toyota, was airlifted to the Royal Victoria Infirmary in Newcastle with serious injuries.
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A statement from the force also said the families of those involved are being supported by specially trained officers.
The M6 northbound fully reopened in the early hours of this morning.
Cops are now appealing for witnesses following the horrific motorway crash.
Cumbria Police said in a statement: "Anyone with information relating to this incident can report online at www.cumbria.police.uk/report-it, quoting incident number 146 of 15 October 2024.
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"You can also phone on 101.
"Alternatively, you can contact Crimestoppers, anonymously, on 0800 555 111."
Glasgow and Cambridgeshire locals along with other social media users wrote of their heartbreak following the tragic incident.
One wrote: "Sad news for all involved. RIP to those poor souls who lost their lives."
Another said: "God bless. R.I.P to the poor souls who lost their lives."
A third called the news "absolutely heartbreaking".