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GABRIEL JESUS was carried off on a stretcher during the first half of Arsenal's FA Cup clash with Manchester United.
The Brazilian, 27, winced in pain as he was replaced by Raheem Sterling.
Jesus hurt himself tangling with Bruno Fernandes.
The forward had raced back to help out defensively on 35 minutes.
When Fernandes appeared to have space to shoot on the edge of the box, Jesus bundled him over.
The Portuguese was furious not to receive a free-kick and even threw his boot in anger.
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As Fernandes complained to the referee, receiving a yellow card for his troubles, Jesus writhed in agony on the ground.
Speaking on the BBC, Theo Walcott said: "Hopefully, Gabriel Jesus will be back soon but it does not look good."
His replacement Sterling was making his return from a knee issue.
The former England man's last appearance came in the League Cup against Crystal Palace on December 18.
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Arsenal are without star man Bukayo Saka, who is expected to be sidelined until March with a hamstring injury.
Ethan Nwaneri, meanwhile, sustained a muscle injury during last week's 1-1 draw at Brighton.
Boss Arteta does have Leandro Trossard available, as well as Kai Havertz and Gabriel Martinelli.
Elsewhere in the team, defenders Ben White and Takehiro Tomiyasu remain sidelined.
Arsenal's next match will see them host fierce rivals Tottenham at the Emirates.
Ange Postecoglou's side got themselves out of an FA Cup pickle earlier, needing extra time to beat non-league Tamworth 3-0.