How Arsenal will line-up against Man Utd with Arteta facing defensive woes and Pepe facing axe yet again

MIKEL ARTETA remains hamstrung by defensive injuries ahead of a must-win game against Manchester United.

The Spaniard looked on course to secure a win in his first home game in charge before two late goals saw his side lose 2-1 to Chelsea.

Pep Guardiola's former assistant began his reign with a draw away at Bournemouth, meaning he will be desperate to earn three points tomorrow.

However, Arteta will likely be forced to put out a makeshift defence once again after Callum Chambers picked up a knee problem in the defeat to the Blues.

Scans revealed the England centre-back may have suffered a serious cruciate ligament injury which could spell the end of his season.

This will see Shkodran Mustafi, who deputised for Chambers on Sunday, start against United following Sokratis' concussion on Boxing Day.

Bukayo Saka has impressed as a makeshift left-back following the injuries to Sead Kolasinac and Kieran Tierney.

The Gunners may be handed a late boost by the return of Hector Bellerin after a thigh-problem, with the Spaniard back in training with the first-team.

One of Arteta's biggest dilemmas remains over club-record signing Nicolas Pepe, who has had to contend with cameo appearances in his first two games in charge.

Former manager Unai Emery was also reluctant to start the Ivorian in the bigger matches, with his successor opting for Reiss Nelson on Sunday.

Granit Xhaka missed the defeat to Chelsea through illness officially but his revelation that he wants to leave Arsenal means Matteo Guendouzi is set once again for the starting XI alongside Lucas Torreira.

Aubameyang looks consigned to operating out wide following Alexandre Lacazette’s return, but Gabriel Martinelli could present a different option if he passes a late fitness test.

Dani Ceballos and Rob Holding are almost ready for selection although Wednesday is still set to come too soon for the pair, with the FA Cup tie against Leeds United on Monday seeming more likely.