, saying: "I don't know much about it except it must be something serious.
"I just got the news and I'm concerned."
He said that Angelina's priority was "always the children".
He said: "It's a sad thing. Say a little prayer."
He later said: "It's a sad time and I'm concerned about the kids and all of that."
The couple announced their engagement in 2012, finally tying the knot in 2014 Credit: AP:Associated Press Brand and Angelina were once the hottest couple in showbiz Credit: Getty Images It was the first time Angelina had publicly admitted to strains in their relationship following years of rumours.
She also said: "Brad has never seen what I'm like when he's left me after one of our fights."
Friends have also spoken out over the marriage breakdown, telling Mail Online the divorce had been brewing for a long time.
The long-time friend of Brad and Angelina said: "When Angelina underwent her mastectomy in 2013, her health and life in general became a priority for her.
"Her views on life changed. Suddenly she saw herself walking in her late mother's shoes and she was no longer that wild, fun-loving woman she used to be. She was taking this more seriously."
Jolie's mother died of ovarian cancer in 2007, with Jolie herself undergoing a double mastectomy in 2013 after discovering she had a gene that put her at high risk of developing breast and ovarian cancer.
The movie star has been married twice before her wedding to Pitt, marrying Jonny Lee Miller in 1995 before marrying Billy Bob Thornton in 1999 after the pair had dated for just two months .
It is the second divorce for Pitt, who was married to Jennifer Aniston from 2000 to 2005.
Pitt and Jolie were married on August 23, 2014, with the movie star wearing a veil covered in an array of doodles designed by her beloved children.
The children also served as ring bearers at the wedding.
Brad and Angelina in wedding mode in a still from Mr and Mrs Smith Credit: Rex Features They fell in love while filming Mr and Mrs Smith in 2005 Credit: WENN Films book-ended the couple's relationship with Pitt and Jolie working together on Mr and Mrs Smith - with speculation spreading that Cotillard was having an affair with Pitt in their latest movie together Credit: AP:Associated Press Brad and Angelina have not been seen in public together since July, when they were snapped by fans on two separate occasions – once at an LA juice bar and at breakfast with their kids on another occasion.
The Internet has since reacted to news of the break up, sharing images of people crying on social media.
Photos of Jennifer Aniston, Pitt's ex, have also been circulated, using previous images of Aniston laughing in her movies to react to the news.
Angelina has been focused on her humanitarian efforts as a Special Envoy for the UN fighting for refugees, while Brad is busy with his multiple acting and business ventures .
Earlier this month Angelina visited a refugee camp in Jordan where she urged world leaders to find a solution to the Syrian crisis.
Meanwhile Brad spent the first part of September in Croatia where he is negotiating a £1billion deal to build a new luxury resort in the coastal town of Zablace, complete with villas, a golf course, shops and a flagship hotel.
The couple have six kids together – Maddox, 15, Zahara, 11, Shiloh, 10, Pax, 12 and eight-year-old twins, Knox and Vivienne.
Maddox, Zahara and Pax were adopted from orphanages in Cambodia, Ethiopia and Vietnam, respectively, while the remaining three are their biological children.
Pitt was granted the right to legally adopt Maddox and Sahara after the couple got together.
The divorce papers show the movie star couple had been married for just two years and one month Credit: Splash News Angelina Jolie Pitt signed the divorce papers on September 19 of this year Credit: Splash News Angelina Jolie has cited 'irreconcilable differences' on the divorce papers, with the star also petitioning that her earnings after the divorce date be separate Credit: Splash News The couple's six children are now in the middle of the split, with Jolie filing for sole physical custody Credit: Splash News The children that Jolie adopted before getting together with Pitt were adopted by the movie star, with the children changing their last name to Jolie-Pitt Credit: Splash News The divorce papers confirm the end of 'Brangelina' Credit: Splash News A copy of papers filed at Los Angeles Superior Court by Angelina Jolie Credit: Reuters The last picture of the couple was taken in July Credit: Xposure Brad and Angelina met in 2005 on the set of action rom-com Mr & Mrs Smith , around the same time as Brad’s divorce from Friends actress Jennifer Aniston.
The relationship was the subject of Hollywood scandal but the couple have always denied any infidelity.
Now attention will turn to the couple's divorce settlement and the distribution of their huge $400 million combined fortune, much of which is tied up in property they've collected all over the world.
Earlier today copies of the divorce papers were released, and show that Angelina filed citing "irreconcilable differences".
She also asked to keep "miscellaneous jewellery and other personal effects", as well as any earnings from after the date of their separation.
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